Ultrasonic Atomization Spraying Equipment for Microneedle Surface Coating

Introduce

Ultrasonic spraying is achieved through ultrasonic atomization technology. The energy of ultrasonic waves disperses water or liquid, forming particles ranging from several micrometers to 100 micrometers in size, which enables the application of ultrasonic waves in spraying. Fansoe can provide different types of atomizing nozzles with the domestic leading ultrasonic atomization technology to help determine the size of droplets, liquid flow rate and spray mode, and the whole machine uses XYZ three-axis servo system to achieve all-round spraying to meet the needs of various fields.

Principle

There are two theoretical explanations for the principle. They are respectively micro shock wave theory and surface tension wave theory.

On the one hand, the theory of micro shock waves explains the cavitation effect of ultrasound in liquid media, which leads to the generation and atomization of micro shock waves. This theory suggests that cavitation effect is the direct cause of liquid atomization. When a cavitation bubble ruptures, except for thermal and optical radiation, all other radiation occurs in the form of micro shock waves. When the micro shock wave reaches a certain intensity, it will cause liquid atomization. When the micro shock wave reaches a certain intensity, it will cause liquid atomization.

On the other hand, surface tension theory suggests that the generation of droplets is due to the instability of liquid surface waves, which causes the atomization of the liquid. Specifically, when a specific sound intensity of ultrasonic waves passes through a liquid, surface tension is formed by the ultrasonic waves at the gas-liquid interface. Once the vibration surface reaches a certain amplitude value at this interface, the force is perpendicular to the surface tension, and the peak of the liquid water droplet flying out forms fogging. This theory suggests that surface tension waves generate droplets at their peak, and the droplet size is proportional to the wavelength.

Ultrasonic spray is an effective method to deposit drug delivery or gene therapy coating onto microneedle patches or arrays. Accurate dosage is achieved by repeatedly depositing thin films on the needle tip without collecting them on the substrate. The mild atomized spray is targeted and controlled to deposit at the required place, regardless of whether there is shielding.

Ultrasonic atomization spraying equipment can apply drug delivery coatings to implantable stents, balloon catheters, microneedle patches, and complex geometries without the need for webbing or excessive material accumulation. With the help of FUNSONIC ultrasonic spray nozzle, the median droplet size is less than 10 microns and the size distribution is tight, which can produce uniform and repeatable spray performance. The coating thickness is as thin as 100 nanometers, with almost no overspray, making ultrasonic spraying technology very suitable for microneedle coatings.